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This study investigated a novel injectable composite conductive hydrogel for tumor treatment. The hydrogel contains a continuous three-dimensional nano-electrode network inside, successfully breaking through the spatial bottleneck of the electrode/electrolyte interface in traditional electrocatalytic therapy. This system can utilize the endogenous chloride ions in the tumor microenvironment to continuously electrocatalytically generate a powerful oxidant, hypochlorous acid, in three-dimensional space. At the same time, it dissolves the platinum components in the material to release platinum ions. The combined effect of these two mechanisms not only directly causes DNA damage to tumor cells but also induces immunogenic cell death and activates anti-tumor immune responses, thereby achieving the synergistic enhancement of chemotherapy and immunotherapy. The related research results were published in the internationally renowned journal "ACS Nano" under the title "Electrocatalysis-Triggered Synergistic Chemo-Immunotherapy Enabled by an Implantable Conductive Hydrogel with 3D Nanoelectrode Network". Innovation Points
01 Construct "Phase-Continuous Electrode"
This research abandoned the traditional single-membrane structure of porous electrodes. By interweaving one-dimensional platinum nanowires with conductive polymer composite microspheres in three-dimensional space, the entire hydrogel became a giant "electrode" with continuous internal electronic pathways, truly expanding the electrocatalytic reaction from a two-dimensional surface to a three-dimensional volume.
02 Achieve "Dual Synergistic Mechanism"
The hypochlorous acid produced by the system not only has its own oxidizing and killing effect, but also acts as a "key" to dissolve platinum nanomaterials and release ions. The oxidative damage and the DNA damage caused by platinum ions synergistically enhance the immunogenic cell death signal and promote the activation of anti-tumor immune response.
Journal Name: ACS Nano Publication Date: March 11, 2026 DOI: 10.1021/acsnano.5c20908 Research Team: Defu Qian, Hongyi Zhang, Fuping Han, Yikun Li, Xin Li, Haolan Li, Yinghua Li, Wen Sun, Jianjun Du, Jiangli Fan, Xiaojun Peng
