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When pathogenic bacteria colonize on the wound, they can create an alkaline ecological niche, by creating an inflammatory environment that restricts the healthy healing of the wound to select for survival. To aid in healing, wound acidification has been used to disrupt this process and stimulate fibroblast growth, increase wound oxygen concentration, minimize proteolytic activity to the greatest extent, and re-stimulate the host immune system. In this study, we developed cobalt-doped carbon quantum dot nanoparticles that can work synergistically with mild acetic acid to create an effective synergistic antibacterial therapy. The acidic environment alters the permeability balance of microorganisms, forcing them to expand and accelerate the internalization of ultra-small particles. These particles cause the bacterial membrane to become hyperpolarized and produce destructive peroxidase substances, leading to cell lysis. In mice, cobalt-doped carbon quantum dots can eliminate MRSA infections while allowing wounds to heal at a rate comparable to uninfected wounds. This work demonstrates how a successful synergistic antibacterial treatment strategy can be used to combat antibiotic-resistant infections. This study was published in ACS Nano under the title "Cobalt-Doped Carbon Quantum Dots Work Synergistically with Weak Acetic Acid to Eliminate Antimicrobial-Resistant Bacterial Infections".
References:
DOI: 10.1021/acsnano.5c03108
