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This study focused on the application bottleneck of bone morphogenetic protein 2 in bone repair and constructed a porous PLGA microsphere delivery system that encapsulates bone affinity peptide fused bone morphogenetic protein 2. This system retains the biological activity of the protein while endowing it with high bone tissue affinity, enabling stable and continuous release of the protein. It can effectively accelerate the fracture healing process and reduce the risk of ectopic ossification. In the repair of osteoporotic fractures, it shows superior healing effects and provides a new technical solution for related research on bone injury repair.
01 Research Background
Bone morphogenetic protein 2 is an active factor with bone formation function. It shows good application potential in complex bone injuries such as osteoporotic fractures. However, this factor is difficult to maintain a stable state in the body and also has the problem of triggering ectopic bone formation. These defects limit its application in the field of bone repair and urgently require technical optimization to solve these core issues.
02 Main Content
The bone morphogenetic protein 2 was molecularly fused with specific bone affinity peptides to prepare a fusion protein with bone targeting ability; this fusion protein was encapsulated in porous PLGA microspheres to construct the D-Bmp2@M delivery system. The study explored the bone tissue affinity characteristics, protein release behavior, and effects on fracture healing and ectopic bone formation of this delivery system, and verified its actual effect in the repair of osteoporotic fractures.
03 Research Design
The modification strategy of molecular fusion was adopted to endow bone morphogenetic protein 2 with bone tissue-targeted binding affinity; porous PLGA microspheres were selected as the carrier to achieve the encapsulation and long-term sustained release of the fusion protein. Multi-dimensional experiments were conducted to verify the protein stability, release cycle, and bone affinity of the system, and its promoting effect on the osteogenic process, inhibitory effect on ectopic bone formation, and repair efficacy in osteoporotic fractures were evaluated in bone injury models. 4. Authors: Pengcheng Ren, Wenqiang Sun, Diaodiao Wang, Yu Zhang, Zhuang Tian, Guanghui Ma, Wei Wei, Qi Yao
