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In response to the treatment challenges of infectious bone defects, this study constructed an engineered polyamino acid hydrogel with continuous antibacterial and osteogenic activation properties. Through in vitro and in vivo experiments, its role in infection control and bone defect repair was verified, achieving a single-stage reconstruction of this disease.
Research Background
The treatment of infectious bone defects is a significant challenge in the field of orthopedics. Traditional treatments require a staged approach to achieve both infection control and bone reconstruction. Based on the content and time characteristics of these two core tasks, designing a dual-functional material with continuous antibacterial and osteogenic promotion functions is an important research direction in this field.
Main Content
This study constructs a hydrogel with specific components through open-ring polymerization. It endows it with osteogenic properties and antibacterial properties through BMP-2 peptide transplantation and vancomycin loading, respectively, to construct a dual-functional engineered hydrogel. The surface characterization, biocompatibility analysis, and antibacterial and osteogenic properties assessment of this hydrogel are carried out, and its in vivo therapeutic effect is verified using a rabbit model of infectious bone defect.
Research Design
Centering on the sequential requirements of infection control and bone reconstruction, a dual-functional hydrogel system with continuous antibacterial and osteogenic activation functions is designed. The physicochemical properties, biocompatibility, and core functions of the material are evaluated through in vitro experiments, and its comprehensive efficacy in the repair of infectious bone defects is verified through an in vivo animal model. Result
The engineered hydrogel constructed possesses the physicochemical properties suitable for research needs. It can rapidly and continuously release antibiotics in the early stage and effectively inhibit both Gram-positive and Gram-negative bacteria in vitro. This hydrogel has good cell compatibility and can promote the differentiation of stem cells towards the osteogenic direction. In the rabbit model of infectious bone defect, this hydrogel can simultaneously achieve infection control and bone reconstruction, accelerating the repair process of the defect.
Thought extension
This study constructs sequential dual-functional materials through a functional integration strategy, providing a new material design idea for the single-stage treatment of infectious bone defects; its core lies in achieving precise matching and coordinated exertion of antibacterial and osteogenic functions according to the time characteristics and functional requirements of the treatment, providing a reference for the development of multifunctional biomaterials.
Original source:
1. Journal: Theranostics
2. Publication date: 2026-01-01
3. DOI: 10.7150/thno.121585
4. Authors: Yutao Cui, Yuhang Tian, Minghan Dou, Shaorong Li, Yi Fan, Gan Wang, Chuangang Peng, Yanbing Wang, Dankai Wu
