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Catalytic therapy demonstrates great potential in cancer treatment due to its precise targeting, high efficiency, safety, and cost control. However, this technology is still limited by several bottlenecks of traditional nano reactors: ① limited tissue penetration ability; ② insufficient H2O2 concentration in the tumor microenvironment; ③ unsatisfactory therapeutic effect of single administration; ④ difficulty in precisely controlling the timing of re-administration.
To address these issues, Professor Fu Qinrui from Qingdao University of Medicine published a research paper in the internationally renowned journal "ACS Nano", titled "Self-Propelled Nanoreactors for Enhanced Cascade Catalytic Cancer Therapy through NIR-II Fluorescence Imaging-Guided Readministration". The research team designed a self-propelled nano-reactor (DSFGC), which integrates second near-infrared fluorescent nanoparticles, peroxidase-like nanoenzymes, and asymmetrically modified catalase and glucose oxidase, aiming to enhance the penetration ability of tumor tissues and precisely determine the re-administration timing based on NIR-II fluorescence imaging, thereby enhancing the efficacy of cascade catalytic therapy. In the tumor microenvironment, the overexpressed H2O2 is catalyzed by hydrogen peroxidase to decompose into oxygen, which not only promotes the penetration of the nano-reactor into deep tumor tissues but also serves as an oxygen source to enhance the catalytic reaction of glucose oxidase, thereby generating glucose acid and self-supplying H2O2. The generated glucose acid can further activate peroxidase-like nanoenzymes, promoting the generation of hydroxyl radicals (·OH). Additionally, the dynamic information obtained through NIR-II fluorescence imaging can precisely guide the timing of re-administration, achieving synergistic enhancement of the starvation therapy and chemical kinetics therapy.
Link to the original article: https://doi.org/10.1021/acsnano.5c17672
