Traditional titanium-based implants are prone to mitochondrial damage and M1 polarization of macrophages in rheumatoid arthritis (RA) bone defects due to a high ROS and hypoxic microenvironment, which hinders bone integration. Researchers have constructed a MnFe₂O₄ nanozyme coating (MFO coating) on the surface of titanium, leveraging its ability to efficiently convert H₂O₂ into O₂ and scavenge ROS.Reduces mitochondrial ROS accumulation and Ca²⁺ overload, maintains O₂ levels to prevent cell apoptosis; activates mitophagy through the Ca²⁺-AMPK-mTOR pathway, restores mitochondrial function, promotes a switch to oxidative phosphorylation, drives macrophage M2 polarization, inhibits osteoclast activity, and accelerates bone integration. This coating provides a new strategy for the design of implants for inflammatory bone defects, with the potential to reduce revision risks and extend service life.

Original link

Nanozyme Coating-Mediated Mitochondrial Metabolic Reprogramming of Macrophages for Immunomodulatory

Osseointegration in Rheumatoid Arthritis Case

ACS Nano ( IF 16 )

Pub Date : 2025-07-08

DOI: 10.1021/acsnano.5c07535

Shimeng Chen,  Xiaoqi Liu,  Wenhui Zhang,  Bo Li,  Fuwei Liu,  Yingang Zhang,  Yong Han